2020
Professor Hui Peng recently published Proteome-wide effects of naphthalene-derived secondary organic aerosol in BEAS-2B cells are caused by short-lived unsaturated carbonyls
Secondary organic aerosol (SOA) causes various adverse health outcomes, but identification of the toxic components remains infeasible for current methodology due to the existence of hundreds of unknown chemical components. In this study, we established a platform to tackle this challenge by combining atmospheric flow reactor, proteomics, reporter bioassays, and nontarget analysis. Short-lived unsaturated carbonyls were identified to be the components in naphthalene-derived SOA responsible for toxicity related to cysteine reactions.